Proton pump inhibitors and gastric mucosal protectors should be taken for duodenal ulcers. The main pharmacological effect of proton pump inhibitors is to inhibit the secretion of gastric acid, reduce the stimulation of gastric acid on ulcers and promote the early healing of ulcers. After taking the gastric mucosal protective agent, it can form a protective film on the surface of the ulcer, which is conducive to the early healing of the ulcer surface, and if there is H. pylori infection, standard anti-H. pylori treatment should be carried out. Duodenal ulcer is a rupture of the duodenal mucosa caused by various etiologies, which eventually forms an ulcer. It often manifests clinically as chronic, periodic, rhythmic epigastric pain and is most pronounced with hunger pain and, in severe cases, blood in the stool and anemia.