Gram-negative bacilli refer to bacteria that react in a red color after Gram staining. Gram-negative bacteria are mainly represented by Escherichia coli. There are many antibiotics available for the treatment of Gram-negative bacteria, such as the common penicillins, macrolides, beta-lactams, which are the third and fourth generation cephalosporins with better effect, as well as carbapenems, quinolones, and aminoglycosides, which can be very effective in the treatment of Gram-negative bacilli. It is better to need to carry out biological culture, but also drug sensitivity test, according to the culture of bacteria and the results of drug sensitivity test, standardized selection of antibacterial drugs. The treatment of antimicrobial drugs is usually curable with timely and standardized selection.