Red and itchy nostrils are commonly associated with colds, nasal vestibulitis, sinusitis, allergic rhinitis, etc. Cold medicines, antibiotics, antihistamines, etc. should be used as prescribed by the doctor for treatment. 1. Cold medicines: Inflammation caused by viral infections during colds can lead to excessive secretion of nasal mucosa, and the stimulation of clear snot triggers red and itchy nostrils, during which it is recommended that cold medicines such as compound aminophenol alkylamine tablets and aminocrystalline capsules be taken according to the doctor’s instructions for the treatment of the cause of colds; 2. Antibiotics: During the onset of nasal vestibulitis and sinusitis, inflammation caused by bacteria and other pathogens can also stimulate the skin of the nasal vestibule to cause redness and itching of the nostrils. It is recommended to take oral amoxicillin capsules, metronidazole tablets and other antibiotics according to the doctor’s instructions, and apply erythromycin ointment and other topical preparations for treatment; 3. Antihistamines: During the onset of allergic rhinitis, non-specific inflammation triggered by allergic factors can lead to congestion and swelling of the nasal mucosa, elevated nasal nerve sensitivity triggering an increase in mucus secretion, resulting in red and itchy nostrils. Patients are advised to stay away from suspected allergens and take antihistamines such as loratadine tablets and levocetirizine tablets as prescribed by the doctor. When red and itchy nostrils occur, patients should actively seek medical advice to clarify the diagnosis and cause of the disease, and standardize the use of medication and treatment.