Low-grade intraepithelial neoplasia of the esophagus is mostly asymptomatic and is usually detected during endoscopic screening, and a small number of patients may present with nausea, vomiting, acid reflux, and retrosternal pain. Low-grade intraepithelial neoplasia of the esophagus is a precancerous lesion, i.e., low-grade intraepithelial neoplasia in which heterogeneous cells involve the epithelial layer and are confined to the subepithelium within the subepithelial 1/2, including squamous epithelium and glandular epithelium. Low-grade intraepithelial neoplasia of the esophagus is mostly asymptomatic and is often detected during endoscopic screening, and a small number of patients may have symptoms such as nausea, vomiting, acid reflux, and retrosternal pain. If low-grade intraepithelial neoplasia is detected during the examination, it is recommended to consult a doctor in time and intervene as soon as possible under the guidance of a professional physician to avoid delaying the condition.