Non-invasive DNA, also known as non-invasive DNA prenatal testing technology, mainly detects whether the fetus has the three major chromosomal disorders. Non-invasive DNA prenatal testing technology is mainly to use a new generation of DNA sequencing technology to sequence the free DNA fragments in maternal peripheral plasma and analyze the results for biological information to get the genetic information of the fetus, so as to detect whether the fetus suffers from the three major chromosomal diseases. The three major chromosomal disorders are Down’s syndrome, Patau’s syndrome and Edward’s syndrome, and their detection rate is over 90%. The test is mainly used in pregnant women whose risk of common chromosomal aneuploidy is between the high-risk cut-off value and 1/1000 on serologic screening. It is also suitable for those with contraindications to interventional prenatal diagnosis, such as preeclampsia, pregnant women with Rh-negative blood type, bleeding tendency and so on. It is recommended that patients choose to undergo non-invasive DNA prenatal testing technology according to their own circumstances and strictly under the guidance of their doctors.