Hepatitis B 1, 4, 5 positive has a certain chance to turn negative, not a lifetime can not turn negative, patients need to actively cooperate with the doctor treatment. Hepatitis B 1, 4, 5 positive refers to hepatitis B surface antigen, hepatitis B e antibody, hepatitis B core antibody is positive, clinically known as “small triple positive”. “Minor triple positive” indicates acute or chronic hepatitis B, but the infectiousness is weak. If the patient actively cooperate with the doctor’s treatment, it can control the condition, improve the discomfort symptoms, and increase the chance of turning negative, not necessarily not turn negative for the rest of their lives. If the patient’s body virus replication is active and liver function is impaired, the patient can follow the doctor’s advice to use ordinary interferon, polyethylene glycol interferon and other interferon-alpha, entecavir, tenofovir and other nucleoside analogs treatment. Patients can also be treated with anti-inflammatory and hepatoprotective drugs such as reduced glutathione and ursodeoxycholic acid. Hepatitis B 1, 4, 5 positive people are recommended to follow the doctor’s instructions for treatment, not to use drugs or prescriptions. During the period of medication, patients should also see a doctor for regular checkups in order to monitor the recovery of the body.