The difference between total glycated hemoglobin and glycated hemoglobin is that the test is somewhat different. Glycated hemoglobin is the product of the reaction of hemoglobin A with glucose, fructose, and other sugars in the body. Hemoglobin A combines with phosphatidylglucose to produce glycated hemoglobin type A, fructose to produce glycated hemoglobin type B, and glucose to produce glycated hemoglobin type C. The clinical term glycated hemoglobin is used to describe the reaction between hemoglobin A and glucose. The clinical term glycated hemoglobin test usually refers to glycated hemoglobin type c. Total glycated hemoglobin is a measurement of the total concentration of a-, b-, and c-glycated hemoglobin; whereas the glycated hemoglobin measurement focuses on the concentration of c-glycated hemoglobin. In fact, plasma c-type glycated hemoglobin accounts for more than 80% of all glycated hemoglobin, which is the decisive factor for the level of glycated hemoglobin, and it is the main object of total glycated hemoglobin measurement. The diagnosis and detection of diabetes mellitus also mainly rely on the c-type, so the role of total glycated hemoglobin and glycated hemoglobin are the same in the clinic, both are important indicators of blood glucose detection and the same detection principle, the diagnosis of diabetes mellitus and monitoring of the condition of the important significance. The difference is that the test object is different, but the main test index is the same. It is recommended to go to the hospital in time if you have abnormal levels of total glycated hemoglobin and glycated hemoglobin.