Mononucleosis generally 1~3 weeks can be good, a few patients with serious conditions, the course of the disease can be prolonged. Mononucleosis is mostly caused by EBV infection, mainly manifested as fever, lymph node swelling, sore throat and other symptoms, self-limiting, mostly good prognosis. 1. Most patients do not need antiviral treatment, and can recover on their own in 1~3 weeks with normal body temperature. 2. A few patients have a long duration of fever and need antiviral treatment, such as oseltamivir, which prolongs the course of the disease. 3. Severe patients, such as complications of fulminant liver failure, severe hemolytic anemia, etc., need urgent treatment of complications, the course of treatment is longer. The same mononucleosis, the patient’s physical condition is different, different stages of the disease, the treatment method is different, should be standardized treatment under the guidance of the doctor.