Normally enemas are painless, but patients with a sensitive anus or the presence of lesions may experience mild pain. An enema is an enema that is prepared by a doctor and poured into the colorectum to diagnose and treat a disease. Generally, the use of a thin plastic tube and the application of the appropriate amount of lubricant will make the enema basically painless. However, patients with sensitive anus or lesions may experience discomfort or mild pain. Enema is a common clinical treatment, but frequent enemas may induce serious complications such as rectal ulcers and rectal gangrene. In conclusion, enemas are not very painful and patients should relax and not worry too much. If serious complications occur, patients should communicate with their doctors in time to avoid serious consequences.