1. Lupus erythematosus is an autoimmune disease with a variety of clinical manifestations that can involve any organ of the body. Lupus erythematosus is a spectrum disease. 2. Early manifestations of SLE are diverse: systemic symptoms: malaise, weight loss, fever, etc. Joint, muscle and bone manifestations: joint pain and swelling are the most common clinical symptoms. Myalgia is a frequent complaint. Skin and mucous membrane manifestations: 80% to 90% of patients with SLE have rash with polymorphic manifestations: facial butterfly erythema, chronic discoid lupus lesions, periorbital edema with purplish redness and capillary dilatation, exudative edematous erythema or polymorphic frostbite like rash on hands and feet (as shown above), vasculitis lesions, purpura, reticular bruises, chronic urticaria, Raynaud’s phenomenon, photosensitive lesions, alopecia, lupus Hair, mucosal damage (conjunctivitis, oral ulcers, lip petechiae, erosions, etc.), renal damage: can cause lupus nephropathy. Cardiovascular system manifestations: can cause pericarditis, pericardial effusion, and myocarditis are also common. Respiratory manifestations: lung and pleura can be involved. Digestive system manifestations: it causes vasculitis and embolism in the blood vessels of the gastrointestinal tract, and can cause pancreatitis. Other comorbidities: Lupus erythematosus can be combined with other autoimmune diseases, such as dry syndrome, primary biliary cirrhosis, leukoaraiosis, etc.