Freckles on hands can be removed by topical medication, laser and freezing. 1. Topical medication: If freckles on hands affect aesthetics, you can apply topical medication, this method is suitable for patients with lighter color, you can apply hydroquinone cream, retinoid cream and vitamin E cream, these medications can lighten the color of freckles, but they can’t eliminate freckles completely. 2. Laser: laser treatment for freckles utilizes the photothermal effect to make the pigment particles disappear. Currently, the commonly used treatments include ruby laser, alexandrite laser and IPL treatment, and strict sun protection is required after laser treatment. 3. Freezing: Liquid nitrogen freezing can be chosen for isolated and lightly pigmented lesions, but this treatment method may cause hypopigmentation or scarring and should be used with caution. The same disease, the patient’s physical condition is different, different stages of the disease, the treatment method is different, should go to the regular hospital under the guidance of specialized doctors for standardized treatment.