It is not based on one’s own feelings to determine the need for folic acid supplementation, but according to the time and according to the results of blood tests and examinations. 1. According to the time: from the first trimester to the second trimester of pregnancy, folic acid supplementation is usually required during this six-month period. Folic acid supplementation can prevent fetal malformations, and it is necessary to take folic acid supplementation under the guidance of a physician’s consultation. 2. According to blood tests: tests are needed to determine whether there is megaloblastic anemia, and if there is such anemia and a lack of folic acid, then it means that folic acid supplementation is needed, and a lack of folic acid can cause anemia. Adverse effects of taking folic acid include nausea, bloating and other gastrointestinal symptoms, and yellowing of the urine can occur with large amounts of folic acid. Megaloblastic anemia caused by vitamin B12 deficiency cannot be treated with folic acid alone, and high doses of oral folic acid can interfere with zinc absorption. In addition, folic acid supplementation, if discomfort occurs, you need to consult a doctor in a timely manner to avoid adverse consequences.