Key Points There is growing evidence to support supplementation with antioxidants, especially in combination with UVB irradiation of the skin. There are no informative studies on the dosing parameters and side effects of oral antioxidants in vitiligo patients. Hydrastis (a fern from subtropical America), ginkgo, melon, alpha-lipoic acid, vitamins C and E, polyunsaturated fatty acids, phenylalanine and other natural substances have been used orally with the aim of increasing systemic catalase activity and thus reducing levels of reactive oxides. Currently, curcumin alone or in combination with capsaicin and resveratrol has been shown to positively affect vitiligo. Solution Experts in the field of vitiligo have a clear preference for this theory – that the appearance and development of white spots is associated with an overall imbalance in the course of the action of the scavenger mechanism. Through the scavenger mechanism, the level of active oxidants in the skin and blood of vitiligo patients is reduced. Therefore topical topical and oral administration of active oxide-reducing substances has been repeatedly advocated. Most of the substances have been mentioned in the main points of this section. In general, some studies have shown that topical or systemic use of “natural antioxidants” has a significant effect on restoration of color, but some studies have shown that they are ineffective. The Scientific Committee on Dermatology tends to recommend oral and topical “natural antioxidants” for the treatment of vitiligo. However, the exact dosing parameters of these natural substances, and double-blind consistent studies with information on their efficacy and safety have yet to be further elaborated.