Grand mal seizures carry a risk of fatalities, and proper first aid is crucial. Epilepsy is a recurrent phenomenon of abnormal neuronal discharge in the brain. Each seizure causes brain cell damage, high disability rate, and is prone to accidental injury or death, which seriously affects the physical and mental health of patients and is a huge burden to families and society. The prevalence of epilepsy in China is about 0.7%, and there are now about 9 million patients with epilepsy, with an annual increase of about 400,000 new cases. Although 70%-80% of patients can control their seizures through antiepileptic drug treatment, there are still 20%-30% of patients who cannot control their seizures despite standard antiepileptic drug treatment and become drug-refractory epilepsy. How to give first aid in case of seizure? When a patient has a generalized convulsion, the patient’s family or rescuer should lay him/her flat to avoid falling. Untie the patient’s collar and pants so that he or she can breathe freely. At the same time, before the patient’s mouth is tightly closed, quickly roll the handkerchief, gauze, etc. into a roll and put it between the patient’s upper and lower teeth to prevent biting the tongue when the teeth are tightly closed. The rescuer or family member should always be at the patient’s side to wipe away the patient’s vomit or oral secretions at any time to prevent suffocation. When the patient is convulsing, do not forcefully press the limb to avoid ligament tears, joint dislocations, or even fractures and other injuries. Do not use the rescue method of acupuncture and acupressure on the human middle point. Do not pour ice water on the patient. If the patient cannot be relieved by prolonged seizures, seek medical attention as soon as possible to reduce the damage to the patient from persistent status epilepticus.