Knee joint closed injection treatment, the main choice of anesthetic drugs lidocaine and hormonal drugs. Repeated punctures may cause local infection, bleeding, or even septic arthritis. In addition, the puncture process may damage important blood vessels or nerves, and the use of large amounts of local hormones may cause local skin color changes and hormone absorption into the blood, which may affect blood sugar and blood pressure. Knee joint closed injection need to go to a regular hospital, the number of times not too often, and the injection process needs to be aseptic operation. It is best to check the blood sugar, if there is diabetes, need good control of blood sugar before doing closed treatment.