Contraindications of estriol ointment include those who are allergic to the product, pregnant or lactating women, etc. Side effects include local burning or itching, breast swelling and pain. Estriol ointment can normalize vaginal epithelial cells, with the effect of restoring the normal flora and physiological pH value of the genitourinary system, enhancing the ability to resist infection and inflammation in the genitourinary system, and is suitable for use in the symptoms of atrophy of the genitourinary tract caused by estrogen deficiency. Indications specifically include improvement of vaginal dryness, itching, painful intercourse, abnormal urination (frequent urination, painful urination, mild urinary incontinence), prevention of recurrent vaginal and lower urethral infections, as well as for use in postmenopausal women for pre- and postoperative vaginal surgery, and for adjunctive diagnosis of suspected atrophic cervical smears. Contraindications to the use of the drug include pregnancy, suspected pregnancy or lactating women, history or suspicion of breast cancer and estrogen-dependent malignancies, undiagnosed vaginal bleeding, untreated endometrial hyperplasia, arterial and venous thromboembolism, porphyria, acute liver disease or a history of hepatic disease that has not returned to normal on hepatic function tests, and allergy to the product. Localized burning or itching, breast tenderness and swelling may occur after use of the drug, usually temporary; the risk of deep vein thrombosis and pulmonary embolism is higher in people on hormone replacement therapy. Specific use of the drug should be under the guidance of a specialist, and should not be used without authorization.