As a strong fortress protecting the brain, the skull plays a pivotal role in human life. However, cranial defects are often caused by collisions with external factors and cranial lesions, which not only make the patient’s overall image look unattractive, but also affect neurological function due to intracranial infection caused by prolonged defects. In the neurosurgery guidelines, it is mentioned that skull defects larger than 3*3 cm need to be repaired in time, and the best time for skull repair is usually within 2-3 months after debridement. Through repair, the patient can have a complete skull and other soft tissues in the skull can function normally. What is the best material for a good domestic cranial repair? There have been many materials used for skull repair, such as animal bone, plexiglass and titanium mesh, which is widely used in clinical practice now. Therefore, titanium mesh is not a suitable repair material for cranial repair. In recent years, very few hospitals in China have taken the lead in introducing new polyetheretherketone as implant material from abroad to carry out cranial repair and plastic surgery with polyetheretherketone peek material to personalize the cranial repair and plastic surgery program to maximize the postoperative natural appearance and reduce postoperative complications. In addition, peek material is a polymer material used for peek repair and plastic surgery, which can be customized in three dimensions before surgery. peek material repair plate can anastomose with the defect area and has excellent performance, and the rejection rate and infection rate are much lower than traditional titanium mesh cranial repair.