If the patient has panic, chest tightness and shortness of breath in the afternoon, there are usually several factors as follows: 1. The most common factors are endocrine disorders and endocrine metabolic diseases, such as hyperthyroidism and hyperadrenocorticism, which can cause cardiac arrhythmia and panic, chest tightness, and shortness of breath in the afternoon. 2. If the patient is a woman, she may have endocrine system dysfunction and estrogen secretion imbalance. If women have endocrine system dysfunction and imbalance of estrogen and progesterone secretion, during menopause, there will be panic, chest tightness and shortness of breath in the afternoon.3. Infectious diseases, especially in the afternoon, the body temperature will rise, such as tuberculosis, rheumatoid arthritis, dermatomyositis, etc., and there will be panic, chest tightness, and shortness of breath in the time of increased body temperature.