Malignant lymphoma is a common tumor of the hematological system, and many people do not know much about this disease, so it is often confused with other diseases. What diseases should be distinguished from malignant lymphoma? Or what diseases should be considered if swollen lymph nodes are found in a certain part of the body? 1. Chronic lymphadenitis: there are obvious foci of infection, often focal lymph node enlargement, pain and tenderness, and redness, swelling, heat and pain during acute attacks, which can be significantly improved by anti-inflammatory treatment. 2.Tuberculous lymphadenitis: often combined with pulmonary tuberculosis, positive OT test, local lesions may sometimes show limited fluctuation or rupture, anti-tuberculosis treatment is effective. 3.Lymph node metastasis cancer: lymph node metastasis cancer lymph nodes are often hard, and their texture varies when multiple lymph nodes are transferred, and the primary foci can be found, rarely the whole body lymph nodes are enlarged. 4.Acute and chronic lymphocytic leukemia: the generalized superficial lymph nodes are often enlarged, hard, non-pressure, non-adhesive, and often have enlarged liver and spleen; bone marrow aspiration and lymph node biopsy show leukemic changes. 5. Eosinophilic lymphogranuloma: Some patients have multiple representative lymph nodes enlargement, clinically resembling malignant lymphoma, with good response to radiation or chemotherapy and good prognosis. Such patients may sometimes have bilateral parotid enlargement, increased number of eosinophils in the blood, and distinctive pathology. 6, infectious mononucleosis: more fever and generalized lymph node enlargement, but abnormal blood picture, positive eosinophilic agglutination reaction can be distinguished. 7, sarcoidosis: In addition to superficial lymph node enlargement, it can also cause hilar lymph node enlargement and pulmonary nodular lesions. A lymph node puncture smear shows a large number of multinucleated giant cells similar to Langham cells, but without caseous lesions. 8, nodular disease: kveim skin test 60%-90% positive; lymph node biopsy showed epithelioid cell granuloma, no R-S cells. 9, giant lymphadenopathy (Castleman disease): a rare lymphadenopathy between benign and malignant. The etiology is unknown and may be a local or systemic infection, with inflammation stimulating lymph node proliferation with the involvement of neurohumoral factors. The main pathological features are significant vascular hyperplasia and hyaline changes or with plasmacytosis due to different antibody reactivity. It is generally classified into three types, namely plasma cell type, hyaline vascular type and intermediate type. There are two clinical types: focal and multicentric, with the former having a limited mass and the latter often having enlarged lymph nodes in multiple locations. The masses are smooth without pressure and some nodes are fused. In some cases of multicentric type, it can be transformed to malignant lymphoma. 10, necrotizing lymphadenitis early, also known as Kikuchi disease or Kikuchi-Fujimoto disease, is a non-neoplastic lymph node enlargement disease, which is a lymph node reactive hyperplasia lesion. It mainly affects young adults and is slightly more common in women than in men. The main symptoms are persistent high fever and enlarged lymph nodes with no or mildly decreased white blood cells. In a few cases, the disease can be recurrent, with multi-organ system involvement or even death. The misdiagnosis rate of this disease can be as high as 30% to 80%. What diseases should be differentiated from malignant lymphoma? After the previous introduction, I believe you have some understanding, once the above traces are found in daily life, you still need to go to the hospital hematology department for detailed and standardized diagnosis and treatment as early as possible.