Weakly positive anti-RO52 antibody indicates that the patient may have dry syndrome, systemic sclerosis, polymyositis, primary biliary cirrhosis and other diseases. Anti-RO52 antibody is one kind of autoantibodies in the human body, and the weak positive of this antibody is related to a variety of autoimmune diseases including rheumatoid arthritis, dry syndrome, etc. However, this index does not have the specificity of the disease, therefore, the weak positive of anti-RO52 antibody can not confirm the diagnosis of the disease, but can only provide the reference for the final diagnosis of the disease. The diagnosis of autoimmune diseases such as rheumatoid arthritis, dry syndrome, etc. should be analyzed in conjunction with the patient’s medical history, signs, symptoms, and auxiliary examination results, and medication and other treatments should be administered for the cause of the patient’s illness. The test results should be interpreted by a professional physician, and it is recommended that patients with weakly positive anti-RO52 antibodies should go to the Department of Rheumatology and Immunology of a regular hospital for detailed consultation.