Plasma donation cannot lower three highs, while three highs cannot donate plasma. Three high cannot donate plasma, because the normal blood donation is usually 200~400ml, while the blood volume of normal adults is around 5000ml. If it is a normal routine blood donation, there is no obvious effect on blood pressure, blood lipids, blood sugar, but if you donate more than 600ml of blood at a time, it may cause a drop in blood pressure, fatigue, dizziness and other symptoms. Lowering the three highs requires standardized treatment, and drug interventions can be applied, such as hypertension drugs, hypoglycemic drugs, and lipid-lowering drugs. Drugs for hypertension can be metoprolol tartrate tablets, etc., which have good efficacy. In case of hyperlipidemia, medications such as atorvastatin tablets and simvastatin can be used. If there is high blood sugar, on the basis of monitoring blood sugar, some hypoglycemic drugs should be used, such as metformin hydrochloride tablets. In addition, donating plasma can not lower the three highs, it is recommended to follow the doctor’s advice to treat the three highs. If you want to donate plasma, you need to strictly abide by the rules of blood donation and meet the conditions before you can.