Chloasma at 50 years old is related to heredity, sunshine, endocrine and other factors, which can be improved by laser treatment, topical drug treatment, endocrine regulation and other comprehensive treatments. 1. Laser treatment: Laser treatment is a common method to remove chloasma. Generally, picosecond laser or carbon dioxide laser can be used to lighten the pigmentation. After laser treatment, it is necessary to pay attention to strict sun protection and moisturizing and hydrating. 2. Topical medication: Melasma is a hyperpigmentation caused by various reasons. Hydroquinone cream or other skin whitening agents or compound preparations of exfoliating agents (e.g. glycolic acid or retinoic acid) can be used externally to lighten the pigmentation. 3. Adjustment of endocrine: for patients who are ineffective in using topical hydroquinone or triple cream alone, oral tranexamic acid and glutathione can be used for combined treatment. It is worth noting that no matter which treatment method is used, it should be carried out under the guidance of doctors, reasonable choice and reasonable improvement.