According to the “Guidelines for Preconception and Pregnancy Care (First Edition)” issued by the Chinese Medical Association’s Obstetrics and Gynecology Branch, the following aspects need to be taken into account in the first trimester of pregnancy: 1. 2. Reasonable nutrition and control of weight gain. 3. supplementation with folic acid 0.4-0.8 mg/d. Pregnant women with previous neurological defects require folic acid supplementation 4 mg/day. 4. women with genetic, chronic and infectious diseases who are preparing for pregnancy should be evaluated and guided. 5. Use medication reasonably and avoid using drugs that may affect normal fetal development. 6. Avoid contact with toxic and harmful substances in the living and occupational environment (such as radiation, high temperature, lead, mercury, benzene, arsenic, pesticides, etc.) and avoid close contact with pets. 7.Change bad habits (such as smoking, alcoholism, drug abuse, etc.) and lifestyle; avoid high-intensity work, high-noise environment and domestic violence. 8. Maintain mental health, relieve mental stress, and prevent the occurrence of psychological problems during pregnancy and after delivery. 9, reasonable choice of exercise.