Many people have the habit of staying up late, some of them are helpless, due to the nature of their profession; others are voluntarily enjoy the night life, the night life as a sign of modern civilization. For the latter, it is simply on a road of no return. During the day, the human organism has been working all day, if the night and then do not get proper rest, the body will certainly be burned out until the strike. There is a proverb that says: “eat a pig during the day, rather than a whistle at night”, its meaning is extremely profound. The medical profession is this evaluation of staying up late: 12:00 before not sleeping is “shameless”, 3:00 am before not sleeping is “not life”. As we all know, the body’s body functions are regulated naturally during the day and night, these rules are the long-term evolution of human beings have long been adapted to and have been “agreed upon” work and rest system, in this work and rest environment, the body between the organs of mutual coordination, each in its own way, to maintain and complete the body’s growth and development, the fight against external germs In this work and rest environment, all organs in the body coordinate with each other and perform their duties to maintain and complete the body’s growth and development, fight against external invasion of germs and other physiological, biochemical and endocrine functions. If a person easily breaks this rule, it will cause a series of disorders in the regulation of human organ functions. Scientists have found that if a person’s rhythm of life is erratic, it will disrupt the normal regulation of circulation in the human body, directly affecting the stability of the internal environment of the human body, which will cause disruptions in the secretion of physiological hormones in the body, and over time will accelerate the degeneration of the organism’s functions, which is the main reason why some people who often stay up late are prone to colds, and proteinuria is not cured. A prospective study in Japan showed that people who slept ≤6 hours had a 70% increased risk of proteinuria compared to those who slept 7 hours or more per night. There is also more evidence that both altered sleep duration and time to sleep can affect kidney function, and that sleep deprivation and frequent night shifts are associated with risk factors such as chronic kidney disease (CKD), hypertension, and coronary heart disease. The effects of staying up late for a long time on the human body are multifaceted, it not only deprives the gastrointestinal tract of rest, leading to peptic gastric ulcers, duodenal ulcers, functional dyspepsia, etc. Staying up late itself puts the body in a state of tension for a long time, causing abnormal vasoconstriction and easily inducing a continuous rise in systemic blood pressure and intrarenal pressure, which are all high-risk factors for hypertension, coronary heart disease and kidney disease. In addition, staying up late can disrupt endocrine hormone levels, making cell metabolism abnormal, affecting the normal division of human cells, leading to cell mutations and increasing the risk of cancer. In short, a person who stays up late for a long time is living the future in advance. Why? Because staying up late often makes your own organs work overtime, accelerating their aging and shortening life expectancy. The frequency and degree of staying up late determines its consequences! The consequence is: 12:00 before not sleeping is “shameless”, 3:00 am before not sleeping is “do not live”!