Erythromycin ointment can cure mild anal fissures, but has no significant therapeutic effect on severe anal fissures. Anal fissure is a chronic ulcerative change of the anal canal tissue from the distal end of the anal dentate line to the anal verge, commonly seen in patients with long-term bed rest or chronic constipation. Erythromycin ointment can avoid complications of anal fissure infection on the one hand and promote the healing of anal fissure wounds on the other hand, thus it can be used for the treatment of mild anal fissure. For severe anal fissures with no obvious therapeutic effect, surgical treatment should be actively carried out at a regular hospital in the Department of Anal and Intestinal Surgery or in the Department of General Surgery, with fissure removal being the main surgical procedure. All in all, after suffering from anal fissures, you should seek medical attention in time and decide on medication or surgery after full evaluation by a specialist, avoiding blind medication to avoid losing more than you gain.