A creatinine clearance of 80 ml/min usually indicates that kidney function is normal, but this condition can also occur in patients with mild kidney disease in the compensatory phase. Creatinine clearance is the ability of kidneys to completely remove the intrinsic creatinine from a number of milliliters of blood per unit of time, which reflects the function of kidneys to a certain extent. The value of creatinine clearance in normal people is between 80 and 120 ml/min. A creatinine clearance of 80 ml/min usually indicates normal kidney function, but it can be seen in two groups of people. One group is healthy adults. The other category is the patients by slight kidney lesions, such as positive urine protein or urine occult blood, etc. At this time, the patients have normal creatinine clearance although there are diseases in the kidneys. Therefore, for patients with normal creatinine clearance, it is still recommended to improve urine protein quantification, urine routine, urine microalbumin/creatinine and other tests to clarify the condition. It is recommended to consult a regular hospital if necessary, and complete the relevant examinations under the guidance of a physician to clarify the diagnosis and treat the symptoms.