1, thyroid crisis: also known as hyperthyroid crisis, or rapidly developing hyperthyroidism or thyroid storm, is thyrotoxicosis in the extreme aggravation of the condition, the patient’s life-threatening serious comorbidities. It is uncommon, but is a serious comorbidity of hyperthyroidism with a high mortality rate. It can occur in Graves’ disease and toxic multinodular goiter. 2, hyperthyroidism heart disease: hyperthyroidism heart disease refers to a series of cardiovascular symptoms and signs of endocrine metabolic disorders such as heart enlargement, cardiac insufficiency, atrial fibrillation, angina pectoris and even myocardial infarction, pathological sinus node syndrome and cardiomyopathy, etc., which are caused by the direct or indirect effect of thyroxin on the heart in the case of hyperthyroidism. Age 15-73 years old, the duration of the disease varies, the longest up to 34 years, the shortest only half a month, the average duration of the disease 10.26 years, the average duration of the disease in men 6.65 years, the average duration of the treatment of women 9.15 years. 3, thyroid eye disease: thyroid eye disease is accompanied by thyroid function abnormality of infiltrative and inflammatory eye disease, mainly occurring in Graves patients, can also be seen in patients with normal thyroid function and primary hypothyroidism and Hashimoto’s thyroiditis patients. In the latter case, only 3% of cases are accompanied by thyroid eye disease. 4, hyperthyroidism chronic myopathy: hyperthyroidism chronic myopathy is a common comorbidity of neuromuscular in hyperthyroidism. In the prominent manifestations of weight loss in hyperthyroidism, hyperthyroid chronic myopathy plays a decisive role. It occurs in 70%-80% of Graves’ disease patients, with a female predominance. 5. Hyperthyroidism combined with periodic paralysis: When hyperthyroidism is combined with periodic paralysis, blood potassium is often reduced. Cyclic paralysis can occur before hyperthyroidism, or when the symptoms of hyperthyroidism are obvious or after remission. This disease is rare in Europe, America, Australia and other countries, while China and Japan are easy to develop countries. It is rare in countries such as Europe, America and Australia, while China and Japan are prone to the disease. In China, it is reported to account for about 3% of hyperthyroid patients, and is more common in middle-aged men. Usually, the disease can be relieved after symptomatic treatment and the use of antithyroid drugs. With the recurrence of hyperthyroidism, cycle paralysis may occur again. 6, hyperthyroidism combined with pregnancy: the incidence of this disease can be up to 0.8%, with Graves’ disease being the most common. 7, blood leukopenia: hyperthyroidism itself, due to the expansion of peripheral blood vessels, or thyroid hormones on the bone marrow, can appear in the peripheral blood leukocytes relative or absolute number of reduction, clinically visible serum leukocytes in the low limit of normal value, after treatment, with the improvement of hyperthyroidism can rise to the normal level. 8, other complications: myasthenia gravis, pernicious anemia, vitiligo, Addison’s disease, diabetes mellitus, pemphigus, rheumatoid arthritis, glomerulonephritis, scleroderma, lupus erythematosus, dry syndrome, idiopathic thrombocytopenic purpura, and autoimmune thyroiditis, and autoimmune thyroid disease accompanied by the disease is not exactly the same. None of these complications are clinically common.