Joint pain in the index finger combined with the palm of the hand may be caused by finger strain or rheumatoid or rheumatoid arthritis. If the index finger is accidentally strained during daily activities, the metacarpophalangeal joint may be injured, and the joint capsule and ligaments may be strained, which may lead to swelling and pain in the index finger combined with the palm of the hand. In addition to pain, there will also be symptoms such as joint swelling, limited movement and weakness. Patients are advised to take proper rest, and if the injury is serious, they can also choose to be immobilized by plaster cast. Rheumatism, rheumatoid arthritis invades the metacarpophalangeal joints, which will also cause swelling and pain in the index finger and palm of the hand. At this time, the joints can be seen obviously enlarged with localized redness and swelling. It can be treated with anti-rheumatic drugs such as Leflunomide, Paeonia lactiflora and painkillers such as Nimesulide and Diclofenac sodium. If there are symptoms of pain in the joints of the index finger and the palm of the hand, it is recommended that the patient go to the hospital for a clear diagnosis and choose regular treatment.