An elevated PSA is often associated with the development of prostate cancer. Of course, acute urinary retention, acute prostatitis, retained urinary catheters, and frequent sexual activity can also lead to elevated prostate-specific antigen. The PSA is found to be elevated in the clinic, so it is important to review it, and for older men, it is important to be alert to the occurrence of prostate cancer. When elevated TPSA is found, if it is accompanied by inflammation or the occurrence of conditions such as retained urinary catheters, it can be retested 1 month after the removal of interfering factors. Diseases such as prostatitis require active infection control, and patients with urinary retention can be retested after removal of the urinary catheter. If the prostate cancer is still high after elimination of related factors, it is necessary to do further prostate MRI to assist in the diagnosis and confirm the diagnosis of prostate cancer or rely on prostate puncture biopsy. The most accurate way to diagnose PSA is to confirm the diagnosis by puncture in time after finding the lesion. In summary, PSA is an indicator to screen for prostate cancer. Once prostate cancer is diagnosed, prostate cancer staging can be evaluated and common treatment modalities include radiotherapy (permanent particle implantation or external radiation), chemotherapy, endocrine therapy and surgery.