Elderly people aged 65 years may be considered for hepatitis B vaccination if they have a high risk of hepatitis B virus infection (history of blood transfusion, application of immunosuppressive drugs, etc.), there are no contraindications to hepatitis B vaccination and they are negative for hepatitis B surface antibody. Newborns, infants and people under 15 years of age who have not been vaccinated against Hepatitis B are the main groups of people to receive Hepatitis B vaccine. Elderly people who are 65 years old and have been tested for hepatitis B, if all five tests, including hepatitis B surface antibody, are negative and the elderly are at high risk for hepatitis B infection, it is necessary to get hepatitis B vaccine. People at high risk of hepatitis B virus infection include: 1. People with a history of injecting drug use, blood transfusion and hemodialysis patients: Hepatitis B virus can be transmitted through blood contact, and timely vaccination can help avoid the risk of infection. 2. Patients suffering from AIDS and using immunosuppressant treatment: these people have lower immunity and weaker resistance to hepatitis B virus infection, so the risk of infection is higher. 3. People with multiple sexual partners and frequent sexual activities: since hepatitis B virus can be transmitted through sexual contact, frequent unclean sex can increase the risk of infection. Contraindications to hepatitis B vaccination include hepatitis, acute seizures of acute or chronic serious diseases, uncontrolled epilepsy; allergy to any component of the vaccine is prohibited. Therefore, hepatitis B vaccination is necessary for 65 year olds to prevent hepatitis B infection, as long as there are no relevant contraindications and the above mentioned vaccination needs are met.