SLE has multi-system damage, so the treatment of SLE complications should be based on the specific condition, and glucocorticoids and immunosuppressants are usually needed. 1. SLE is a systemic autoimmune disease with multi-system damage, so there are various complications of organ involvement, such as lupus nephritis, lupus pneumonia, lupus encephalopathy. 2. Treatment requires the use of high-dose glucocorticoids, and even glucocorticoids such as methylprednisolone sodium succinate shock therapy when necessary; at the same time, immunosuppressants such as moratorium mescaline, azathioprine and cyclophosphamide should be used in time. If necessary, Belimumab can be used, and according to different organ damage to give symptomatic supportive treatment. 3. Long-term use of glucocorticoids and immunosuppressants can lead to complications such as infection, atherosclerosis and osteoporosis. The drugs should be used according to the specific situation, such as infection needs to be actively anti-infection such as cefuroxime and other treatments, such as osteoporosis needs to be given to supplement calcium, vitamin D and phosphate preparations and other treatments. The above medications must be used in accordance with the doctor’s prescription. SLE patients, regardless of whether there are complications or the severity of complications, need to go to the rheumatology and immunology department of the hospital for treatment and follow-up.