Hot heartburn in the stomach, which can also be referred to as heartburn and heartburn, is commonly associated with peptic ulcers, gastroesophageal reflux disease, and chronic gastritis. Different causes have different treatment programs. 1. Peptic ulcer: typical symptoms of epigastric pain, the nature of a dull pain, burning pain, distension, etc., part of which can be manifested as belching, acid reflux. Treatment is divided into the following points ① inhibit gastric acid secretion: ranitidine, famotidine, omeprazole; ② protection of gastric mucosa: bismuth potassium citrate, aluminum thioglycollate; ③ endoscopic treatment: peptic ulcer combined with pyloric deformity or stenosis caused by obstruction, the first choice of endoscopic treatment. 2. Gastroesophageal reflux disease (GERD): reflux and heartburn are the most common and typical symptoms. Therapeutic drugs include: ① acid-suppressing drugs: rabeprazole, famotidine, ranitidine; ② gastrointestinal stimulants: domperidone, mosapride, itopride. 3. Chronic gastritis: it can be manifested as middle and upper abdominal discomfort, fullness, dull pain, burning pain. Therapeutic drugs are: ① Helicobacter pylori-associated gastritis: a four-combination regimen of 1 proton pump inhibitor (e.g., rabeprazole, omeprazole) + 2 antimicrobial drugs (e.g., clarithromycin, amoxicillin) + 1 bismuth (bismuth potassium citrate); ② duodeno-gastric reflux: gastric mucosal protectants, such as misoprostol, aluminum thioglycollate. The appearance of burning stomach discomfort, should be early consultation, clear cause, under the guidance of professional doctors for standardized treatment. Drugs need to be used under the guidance of a professional physician, and should not be used arbitrarily on their own.