Ductal adenocarcinoma of the prostate is one of the rare histologic types of tumors of the prostate in addition to the common follicular epithelial adenocarcinoma,
Ductal carcinoma of the prostate, once known as adenocarcinoma characterized by endometrioid carcinoma, papillary carcinoma, and endometrioid carcinoma, accounts for approximately 0.8% of prostate adenocarcinomas, as it is thought to arise from the prostatic capsule, the male equivalent of the uterus.
The clinical presentation is similar to typical alveolar prostate cancer, with cystoscopy revealing a polypoid, brittle mass protruding outward from the opening of the prostatic capsule and its adjacent ducts located at the tip of the seminiferous tubercle. The cystoscopic examination should be done to differentiate it from uroepithelial carcinoma. The serum PSA may be normal and most of them are accompanied by adenovular prostate cancer.
Different histologic types of tumors have different biological characteristics, and appropriate clinical management depends on the understanding of their biological characteristics and proper diagnosis.
Ductal adenocarcinoma is still considered to be a subtype of epithelial adenocarcinoma of the prostatic follicle and has the same prognosis as the follicular type.