Condyloma acuminatum is a common clinical condition. The high recurrence rate has always been a difficulty in clinical treatment, with 3%-95% of patients suffering from recurrence. The recurrence interval varies from 1 week to half a year, but most of them are around 1 month; the number of recurrences varies, and a few patients can have more than 10 recurrences. The most common method to reduce the recurrence rate of warts is to use topical imiquimod cream, but the long treatment period (12 weeks), many adverse reactions (erythema, burning, rupture, etc.), and expensive factors limit its use in the clinic. The two key factors for recurrence of warts are related to subclinical lesions and HPV latent infection, but there is a lack of specific diagnostic methods and direct treatment for subclinical lesions and HPV latent infection in the clinic. After conventional laser removal of warts, although the local warts are removed, it is not possible to further deepen or expand the treatment area, and often cannot completely remove HPV infection, which is one of the reasons for the high recurrence rate after laser and other treatments.ALA is a precursor of the hemoglobin synthesis process in vivo, which can target enrichment in tissues with significant proliferation, high metabolic status, high viral load and active replication, including clinical, It is then converted into porphyrins such as protoporphyrin IX, which is excited by red light at 635am to produce reactive oxygen species and kill proliferating cells, causing necrosis and apoptosis in HPV-infected tissues, resulting in good therapeutic effects with minimal damage to normal tissues.