In recent years, nearly 1,000 cases of perianal and intra-anal warts have been treated and followed up, and many of them are due to anal intercourse infection leading to intra-anal warts and anal canal warts. Because of the special location resulting in inconvenient treatment and easy recurrence. The actual fact is that you can find a lot of people who have been in the marketplace for a long time. The actual method is: first perianal local anesthesia, laser or microwave to remove the visible warts, two weeks after the wound healing will be soaked in Chinese medicine medicine gauze into the anal area, once a day, each time placed for about 3 hours, even 4-5 days, warts many patients after two weeks and then plug a cycle. Finally, topical application of Imiquimod is used for 12 weeks. The treatment process can be combined with immunomodulators such as thymopentin, photodynamic therapy and Chinese herbal medicine internal and external bubbles. After this step of comprehensive treatment, patients with very severe intra-anal warts have obtained good results. More than ten patients with giant warts have been followed up to date (more than 1 year) without recurrence and successfully cured of complex giant warts with HIV infection, combined with post-renal transplantation, combined with aplastic anemia, etc. The trust and mutual cooperation between the doctor and the patient throughout the treatment process is also very important and beneficial to the treatment.