The diagnosis of condyloma acuminatum is generally not difficult based on the characteristics of the rash, site of onset, and development combined with a history of possible contact inquiries. Subclinical infections can be isolated or coexist with typical lesions and can be confirmed with a white acetate test or toluidine blue test. For latent infections, in situ hybridization or polymerase chain reaction (PCR) can be used to confirm the diagnosis. (1) Lichen planus: flat, moist papules, often fused and not narrowly basal, with syphilis spirochetes and positive syphilis serology. The rash is located on the inner side of the labia minora on both sides, and is a cluster of non-fused fish-roe or polypoid papules, which are granular or soft to the touch, light red, moist, and generally without conscious symptoms, with some mild itchiness. (3) Penile pearly papules: mostly seen in young adults, pearly translucent papules in the coronal sulcus, white, yellowish or red, cone-shaped, spherical or irregular, arranged in one or several rows along the coronal sulcus, or even wrapped around a circle, without obvious symptoms. (4) Bowen-like papulosis: the rash often consists of multiple pigmented papules, or may appear singly, scattered distribution or tendency to cluster, arranged into lines or rings, serious fusion into plaques, slow development (months or years), the disease is in situ squamous carcinoma, or from the development of condyloma acuminata. This disease is slightly more in women, the distribution of sites mainly in the labia majora and minora, perianal. (5) Sebaceous ectopic disease: papules within the mucosa, without overlapping growth, mostly yellowish. (6) Sebaceous gland hyperplasia: yellowish papules, non-tipped, non-spiny, non-overlapping, non-confluent. (7) Paracortical gland hyperplasia: skin-colored or pale red papules arranged in pairs on both sides of the prepuce tether, some with mildly spiny surface visible. The papules are not narrow at the base and are corn or pinhead in size, with no obvious conscious symptoms.