Condyloma acuminatum, also known as genital warts and venereal warts, is a benign proliferative disease of the skin and mucous membranes caused by the human papilloma virus. There are more than 20 HPV subtypes that can cause warts, the common ones are HPV-6, 11, 16, 18, 31, 33, and more than 90% are caused by HPV-6 or 11. Certain HPV subtypes are associated with the development of tumors, such as HPV 16 and 18 are highly carcinogenic and HPV 31, 33 and 35 are moderately carcinogenic. The disease is mainly transmitted through sexual contact, and a few can be transmitted through indirect contact. The incidence of condyloma acuminata in China has increased in recent years. The incubation period of condyloma acuminata is about 3 weeks to 8 months, an average of 3 months. The disease is most likely to be found in the external genitalia and perianal area. In females, they are found in the perineum, labia majora and minora, vaginal opening, vaginal wall, cervix, urethra, mons pubis, and groin. Pregnancy can cause warts to recur and grow faster, possibly related to altered estrogen levels. They are occasionally seen in areas other than the genitalia, such as the armpits, umbilicus, and breasts, and may appear in the oral cavity in cases of oral sex. People who are circumcised or have excessive leukorrhea are susceptible to infection or recurrence. The surface of the warts is white, dark gray or red due to the impregnation of the secretions, and they bleed easily. The warts on the cervix are generally well-defined and small, with a granular, furrowed surface without the typical papillary pattern. Cancer-like condyloma is associated with HPV-6 and 11 types, and a few may become malignant. In addition, there is HPV subclinical infection, which is a localized lesion that appears to be normal skin, but is difficult to detect with the naked eye. About 70% of patients with condyloma acuminatum have no conscious symptoms. A small number of patients may feel itchy, foreign body, pressure or burning sensation, often bleeding or secondary infection due to increased fragility of the lesions. Women may have increased vaginal discharge. Laboratory tests 1, white acetate test After local cleaning, use a cotton swab dipped in 5% acetic acid solution applied to the lesions to be examined and the nearby skin mucosa, generally in 2 to 5 minutes after the infection becomes white, while the surrounding normal tissue does not change color. 2, histopathology Keratinization is incomplete, the spiny layer is highly hypertrophic, papilloma-like hyperplasia, epidermal protrusions can be extended, and the boundary between epidermis and dermis is clear. The granular layer and the upper cells of the spiny layer have obvious vacuole formation, the vacuole cells are large, the cytoplasm color is light, the nucleus is concentrated, deep staining, and there is a transparent halo around the nucleus, the vacuole cells are the characteristic pathological changes of the disease. The dermal capillaries are dilated and surrounded by inflammatory cell infiltration. Diagnosis According to the patient’s history of unclean sexual intercourse, the history of infection or indirect contact with sexual partners or spouses; as well as the characteristics of the lesions, the site of onset, positive white acetate test, it is generally not difficult to make a diagnosis. The aim of treatment is to remove as many visible warts as possible and to reduce recurrence. The actual fact is that you can find a lot of people who are not able to get a lot of money from the internet. The choice of treatment method depends on the size, number, location, lesion pattern, the patient’s wishes, and economic conditions. Some patients require multiple treatments and thus should be followed up every 1 to 2 weeks thereafter. Other STDs that may be associated with the disease should also be treated promptly and effectively.