Rheumatoid arthritis may lead to symptoms of generalized numbness, but such symptoms may also be caused by emotions, diabetic peripheral neuropathy and other reasons. 1. Rheumatoid arthritis: rheumatoid arthritis mainly involves the peripheral joints of the human body, and the common symptoms include joint swelling, joint pain and morning stiffness, which is specifically manifested in the joints of the patient’s stiff and uncomfortable feeling when he/she gets up and moves in the morning, but it can be alleviated after activities. If the disease involves the nervous system, numbness may occur all over the body. 2. Emotions: the body’s emotional tension can cause vegetative nerve dysfunction, at this time the patient will appear the symptoms of generalized numbness. 3. Diabetes: diabetes can damage the patient’s peripheral nerves and cause peripheral neuropathy, patients will have abnormal sensation, numbness of the limbs. Numbness of the whole body may also be caused by other reasons, it is recommended that the patient to the regular hospital rheumatology and immunology department and other related departments to further clarify the diagnosis.