Demyelination usually refers to demyelinating diseases, and the content of the exercise is related to the classification of the disease, the specific dysfunction, and there is no such thing as the best exercise. Demyelinating diseases are a large group of disorders characterized by loss of nerve myelin sheaths and relatively minor damage to neuronal cells and axons. This group of diseases can occur in both the peripheral and central nervous systems, and is best represented by multiple sclerosis and Guillain-Barré syndrome, respectively. The main exercises for multiple sclerosis include joint range of motion training, plyometrics, anti-spasticity training, and relief of tremor and ataxia through anti-gravity exercises. The main exercises for Guillain-Barré syndrome include training to promote scapular stability, stimulating muscle strength through tapping or pressing, and gradually restoring lower extremity stability and walking function through hip flexion, knee flexion, and ankle flexion movements. Once the diagnosis of demyelinating disease is confirmed, rehabilitation training needs to be carried out in a timely manner according to the doctor’s advice after the condition is stabilized to avoid complications such as muscle atrophy and joint contracture.