Itchy small blisters on the soles of the feet should be treated according to the cause of the disease, if it is caused by ringworm of the feet can be general treatment, drug treatment, if it is caused by eczema can be general treatment, drug treatment. 1. Tinea pedis: Tinea pedis can cause blisters and itching on the soles of the feet, general treatment includes wearing loose and breathable shoes and socks, keeping the feet clean and dry, avoiding scratching, medication includes topical medication and oral medication, topical medication such as clotrimazole, amorphophine cream, etc., and when the symptoms are severe, you can follow the doctor’s instructions with oral medication such as terbinafine and itraconazole. 2. Eczema: the general treatment of eczema includes actively searching for and detaching from allergens, reducing external stimuli, maintaining local dryness, medication can be prescribed topical glucocorticosteroids such as halometasone cream, etc., but also under the guidance of the doctor orally loratadine, cetirizine and other antihistamines to relieve itching. It may also be caused by other reasons, it is recommended that the patient go to the hospital in a timely manner to clarify the cause of the disease after treatment. All of the above medications should be used under the guidance of a doctor, avoid self-medication.