In recent years, many new ultrasound diagnostic techniques such as three-dimensional imaging, second harmonic backscattering, acoustic imaging, etc. are used in the diagnosis of breast diseases, which has the advantages of convenient examination, strong sensitivity, no damage, no side effects, moderate price, etc., and has become the preferred method of non-invasive examination of breast diseases. It can clearly show the level of breast tissue and the internal structure of the lesion, especially can find the size of several millimeters of the lesion, so the detection rate of small lesions of breast tissue is quite high, and the application of “breast nodule” as a report of small masses become a routine conclusion. What is the nature of breast nodules? How to treat breast nodules? How to prevent regrowth of breast nodules? These are the most important concerns of patients, and are also the focus of my current research program. 1, what is breast nodular disease breast nodules is not the name of the disease, nor is it the characterization of the disease. It is only a generic term for the ultrasound diagnosis describing a tiny mass in the breast, i.e., a definition of a tiny mass in the breast, so it can only be referred to as breast nodulopathy. So what exactly is the nature of breast nodules? According to the Breast Surgery Department under ultrasound surveillance of breast lesion excision surgery 766 cases, the excision of lesions 2757, an average of each side of the breast excision of lesions 3.59. The age was 13 – 53 years old, with 255 cases on the left side, 215 cases on the right side, and 296 cases bilaterally. A maximum of 38 lesions were excised from one side of the breast through one puncture hole. Results: postoperative pathology reported: 481 cases of breast fibroadenoma, 139 cases of cyst, 101 cases of hyperplasia with fibroadenoma formation, 41 cases of mammary adenopathy, one case of intraductal carcinoma of the breast, and 3 cases of invasive ductal carcinoma. Two or more pathologic changes were present in 39% of them. Biopsy of 206 breast masses in 140 cases and complete excision of the masses were performed using the Mammotome minimally invasive rotary excision system under the monitoring of ultrasound images. Results Pathologic findings of 140 cases (206 masses): 4 cases of invasive ductal carcinoma, 2 cases of ductal carcinoma in situ, 6 cases of intraductal papilloma, 58 cases of fibroadenoma, and 70 cases of fibroadenopathy and hyperplasia. In other words, the clinicians confirmed by the pathology of the surgical removal of small nodular masses, including “benign tumors such as mammary fibroadenoma, mammary adenofibroma, “mammary adenopathy and hyperplasia” sexual lesions and a relatively small number of malignant tumors, “breast cancer”. “. Tiny nodular lesions in the breast, which can also be described as small breast lumps, are early signs of breast diseases and can also be described as the seedling state of tumors. So it should not be taken lightly, and should be emphasized and proactively treated. 2.How are breast nodules formed? Breast nodule is a tiny swelling in the breast, which is a pathological manifestation of the physiological metabolic process of the breast. The incidence of breast nodules is increasing year by year, which is related to changes in dietary habits, life rhythm and environment. It may be closely related to endocrine disorders, relatively high estrogen/androgen ratio or enhanced local aromatase action in the breast, increased local estrogen formation, resulting in malfunctioning of breast cell proliferation and rejuvenation, i.e., mutation of breast cells, disorders in arrangement, increase in number, physiological metabolic derangement, and accumulation of pathological foci to form lumps. Because the nodule is a breast disease of the presence of the body, including the breast fibroadenoma, breast adenofibroma and other benign tumors, breast adenopathy proliferative lesions or malignant tumors breast cancer. Its pathological mechanism is related to the above mentioned related breast diseases. 3.How can clinicians identify benign and malignant nodules? In principle, the nature of breast lumps and nodules should be based on pathological diagnosis, but clinically patients often need doctors to give an impression of the diagnosis, I suggest referring to the following indicators: (1) Judgement from the age: if the age of the person is small, the probability of benign lesions is high, and if the age of the person is large, the probability of malignant is relatively high. (2) Family history: those without a maternal family history of breast cancer have a higher likelihood of benign lesions, and those with a maternal family history of breast cancer have a higher likelihood of relatively malignant lesions. (3) Number of nodules: those with many nodules are more likely to be benign, and those with single nodule are relatively more likely to have malignant breast cancer. (4) Nodule morphology, hardness, smoothness, tenderness, activity: palpation of the lump nodule is round, oval with clear boundary, smooth, tough, good activity, no tenderness or tenderness, high possibility of benign. The lump nodule is irregular, unclear boundary, not smooth, hard texture, small mobility, no pressure pain. Enlargement of axillary lymph nodes is obvious, and there is possibility of breast cancer. (5) The growth rate of the nodes: if the growth rate of the nodes is slow, the possibility of benign is high; if the growth rate of the nodes is fast, the chance of malignancy is high. (6) Ultrasound: the breast tissue can be round, oval, flaky or triangular regular, irregular or irregular lumps and nodules. The boundary of the lump is clear, relatively smooth, mostly with lateral acoustic shadows, and may also have angular protrusions. The lump is often compressive, with no obvious reverse motion when pressed, no blood flow or small amount of blood flow signal, then it mostly shows peripheral type of blood flow, rarely penetrating type of blood flow, with uniform echogenicity, and neat, enhanced and clear echogenicity of the posterior wall, which is mostly a benign breast lesion; under-regulated or irregular lumps and nodules are seen in the breast tissues, with unclear borders, burr-like or crab-foot-shaped, with rare lateral acoustic shadowing, and irregular, attenuated, and unclear echogenicity of the posterior wall (6) The tumor should have a moderate amount of blood flow and abundant blood flow signals, mostly penetrating blood vessel distribution, and a few peripheral blood flow, which are mostly malignant lesions of the breast. (7) Molybdenum target suggests: the lump nodule is round, oval, semicircular and petal-shaped, with clear boundary and smooth peritoneum, or isolated, dense, scattered nodules, with density similar to that of the gland, or slightly higher than that of the gland. Foci of round, circular punctate, small patchy and striated calcification are seen. The nodules are irregularly shaped, with unclear borders and no periphery, rough burr-like edges, high density, and foci of forked, rod-like (acicular) slough-like and clustered calcifications. Around the lump nodule can be seen tortuous expansion, dense formation of network distribution of heterogeneous blood vessels. 4.How to treat breast nodular disease? As breast nodular disease is a substantial swelling in the breast, including benign tumor, breast hyperplasia, breast cancer, the possibility of self dissipation is very small, at present, in addition to pathological section diagnosis, it is difficult to clarify the nature of the non-invasive diagnosis alone. Most of the patients are worried about the possibility of malignant changes, but also fear of surgical resection, and fear of postoperative recurrence. According to clinical observation, most of the nodules for bilateral breast multiple, scattered, given surgery, regeneration and reoccurrence is very strong, and even many times surgery repeated episodes, not only damage to the breast tissue, but also destroy the aesthetic appearance of the breast, so that the patient’s physical and mental pain, but also the doctor is very helpless. In recent years, I put this disease as the focus of research, achieved more satisfactory results, the treatment is: (1) small trauma cosmetic surgery method: that is, for larger lumps (> 1cm), hand palpable single or multiple lumps, it is recommended that conventional surgical treatment. However, the surgery is aimed at small incision, accurate positioning, blunt separation along the edge of the tumor, no or little damage to the breast tissue, careful and serious cosmetic suture, no scar in the prognosis, and does not affect the function of breastfeeding. In order to stop and prevent the regeneration of lumps and nodules after the operation, internal medicines such as “Apocrine Tumor Dispersing Pill” are taken to regulate the endocrine function, so as to cure the disease fundamentally. (2) Minimally invasive surgery method: i.e., if the hands are unable to reach the scattered and multiple tiny nodules, and the patient is in urgent need of treatment, the patient can choose the minimally invasive surgery of McMurtagh’s ultrasound-guided vacuum-assisted high-speed rotary incision under computer control. (3) Apoptosis and Dispersal Method: Because breast nodules or fibroadenomas are mostly multiple and highly regenerative, there is no effective drug on the market for treating breast nodules, which we have studied as a key project, i.e., the application of traditional Chinese medicine and biological agents, internal and external, to achieve the effect of softening and dispersing the nodules and to make the tumor cells apoptotic and the nodules shrivel up and disappear. Through clinical observation, a part of nodular masses (0.8L) can disappear completely, and a part of lumps and nodules can be reduced significantly; post-surgery patients can be prevented from regeneration after taking the medicine, and the number of recurrences can be reduced significantly. (4) Applying infiltration method: biological agents, thin plasters, attached to the local skin of lesions, so that the drugs directly penetrate into the tumor nodules locally, prompting the apoptosis of tumor cells and the disappearance of nodular masses by atrophy. It is suitable for all kinds of tumors, nodules and hyperplastic masses.