How long it takes for Rituximab to work in treating kidney disease needs to be assessed according to the severity of the disease and cannot be generalized. However, it is more common for the treatment to take effect in about 3 months. Rituximab is a biological agent, which can be used to treat kidney diseases, such as nephrotic syndrome or lupus nephritis. However, different kidney diseases have different degrees of severity, and the duration of the medication and the time to see the effect are also different. If the kidney disease is in the early stage, the condition is not particularly serious, the use of rituximab treatment, may be able to see the effect of 1 ~ 3 months; but if the onset of kidney disease is longer, the disease is more serious, usually the drug treatment time usually need 3 ~ 6 months to see the effect of the disease, or even the treatment time needs to be longer. It should be noted that rituximab is contraindicated for those who are allergic to the components of the drug, pregnant and breastfeeding women, acute stage of rheumatoid arthritis, and those with severe heart failure. The drug needs to be used under the guidance of a doctor, avoid self-medication. Patients with kidney disease are advised to go to regular hospitals in time and give targeted treatment or therapy under the guidance of doctors.