Why chronic lower extremity ischemia is not only a lesion of the blood vessels in the legs The vast majority of patients with chronic lower extremity ischemia have pathophysiological manifestations that are based on atherosclerosis. And the condition of lower extremity atherosclerosis generally develops along with the development of systemic atherosclerosis. Patients with lower extremity arterial lesions are often combined with lesions of coronary arteries, lesions of head and neck arteries, lesions of aorta or visceral arteries, lesions of small intracranial arteries, etc. The degree of development of lesions at these sites may vary, but they are all affected by a combination of risk factors such as hypertension, hyperglycemia, and hyperlipidemia. Therefore, for the treatment of chronic lower limb ischemia, in addition to treating the vascular lesions in their lower limbs, attention should also be paid to the presence of vascular lesions in other sites, as well as to the treatment of high-risk factors.