When Metformin Hydrochloride Extended-Release Tablets are taken at the same time as Glimepiride Dispersible Tablets, Metformin Hydrochloride Extended-Release Tablets are usually taken with or after a meal, and Glimepiride Dispersible Tablets are taken with a meal at breakfast or the first main meal. Metformin hydrochloride extended-release tablets can be taken in divided doses or as a single dose. The starting dose range is 500 -2000mg/d, with gradual increments recommended from the smallest dose. Clinically, 1.0 g is taken orally twice daily or 0.5 g three times daily. It is generally recommended to be taken with or after meals or at bedtime. Glimepiride dispersible tablets are usually started at a dose of 1 to 2 mg per day for adults, given with breakfast or the first main meal. The maximum starting dose should not exceed 2 mg per day, and the maintenance dose is 1 to 4 mg per day, with the dose adjusted according to the patient’s blood glucose changes, and the dose should not be increased by more than 2 mg per day every 1 to 2 weeks.The maximum recommended maintenance dose is 6 mg per day. The combination of metformin and glimepiride should be noted for adverse reactions such as hypoglycemia, nausea and vomiting, diarrhea, and impaired liver function. It is contraindicated in patients who are allergic to both, acute complications of diabetes, pregnant women, lactating women, severe hepatic and renal insufficiency. Use with caution in patients with debilitated body, the elderly and other patients. Diabetic patients using metformin extended-release tablets and glimepiride dispersible tablets at the same time, should consult a regular hospital under the guidance of endocrine specialists, and regular monitoring of blood glucose, do not use blindly to avoid adverse reactions.