Palmoplantar keratosis is characterized by diffuse or limited thickening and hyperkeratosis of the palmoplantar skin. It can be treated with retinoids, and also with topical medications such as keratolytic agents and glucocorticoids. 1. Oral medication: Vitamin A can be taken, such as avitamin A, isotretinoin, etc., which can promote the proliferation and differentiation of epidermal cells, as well as dissolve keratin, thus improving the role of palmoplantar keratinization. 2. Topical medication: For patients with mild symptoms, it is generally recommended to apply medication externally, such as commonly used keratolytic agents such as salicylic acid, retinoic acid ointment, urea cream, etc., which can be used to seal and soften the keratin and relieve the discomfort of cracking and pain. Secondly, topical glucocorticoid medications such as hydrocortisone ointment and dexamethasone ointment can also be applied to the lesions to improve the therapeutic effect. When the palmoplantar keratosis, you need to go to the hospital in time, under the guidance of the doctor to choose the appropriate drugs for standardized treatment, to avoid blind use of drugs.