Large gaps between teeth may be caused by over-small teeth, periodontitis, jaw deformity, etc. They can be restored by general measures, medication, surgery, etc. 1. Over-small teeth: The gap between the teeth is large due to the smaller than normal size of the teeth, which can be restored to the normal shape of the teeth by removing the gap through resin crown restoration, light-curing resin restoration, and so on. 2. Periodontitis: Because periodontitis will lead to gum recession, so it will increase the gap between neighboring teeth, and there will be red and swollen gums, loose teeth, bleeding and other symptoms. If there is tartar, patients need to cooperate with the doctor to take supragingival scaling, subgingival scaling. At the same time need to follow the doctor’s instructions to use amoxicillin, cefuroxime and other antibiotics. If the symptoms are serious, surgical treatment such as flap surgery and bone grafting should be performed. 3. Jaw deformity: For patients with jaw deformity, active orthodontic appliances, fixed orthodontic appliances, functional orthodontic appliances and other orthodontic treatment should be taken according to the actual situation. It is recommended that patients with large gaps between their teeth should go to the hospital to clarify the specific causes and cooperate with the doctor for active treatment.