Bone metastasis and thigh pain are mainly treated by actively treating the primary disease and at the same time cooperating with painkillers to treat the symptoms. Bone metastasis is mainly caused by lung cancer, breast cancer, prostate cancer, kidney cancer, etc., which metastasizes to bone tissue through blood line and causes bone damage, and patients will have severe pain, pathological fracture, hypercalcemia and other related manifestations. The main method for patients with bone metastasis leg pain is to treat the cause, actively carry out anti-tumor treatment such as radiotherapy, chemotherapy, palliative surgery, etc., to control the metastasis of the primary disease. At the same time, it is also necessary to carry out symptomatic treatment for the symptoms caused by leg pain, you can take Tramadol hydrochloride tablets and other painkillers to relieve. As the bone metastasis has caused some damage to the bone, zoledronic acid for injection can also be used to reduce or delay the occurrence of bone-related events. Patients are advised to actively pursue treatment in cooperation with their doctors to improve their quality of life.