Indirect bilirubin high hemoglobin high splenomegaly, may be viral hepatitis, drug liver disease, cirrhosis, etc., need to symptomatic treatment, dietary modification. 1. Viral hepatitis, drug induced liver disease: structural changes or damage to the liver may lead to liver function abnormalities, high indirect bilirubin, long-term may be transformed into hepatic insufficiency, attention should be paid to dietary modification, medication (e.g. glycyrrhetinic acid preparation, reduced glutathione, etc.), smoking cessation and cessation of alcohol, antiviral therapy (e.g. acyclovir). 2. Cirrhosis: it can cause liver function decline, jaundice leading to high indirect bilirubin; splenomegaly due to portal hypertension; increased burden on kidneys and decreased glomerular filtration rate leading to elevated hemoglobin. Ursodeoxycholic acid can be taken to ensure the right amount of intestinal protein, reduce the metabolic burden of the liver, use spironolactone, furosemide and other diuretics to relieve biliary obstruction and so on. It is difficult to determine the cause of the disease only by relying on high indirect bilirubin, high hemoglobin and splenomegaly, and further examination is needed, so it is recommended to go to the hospital in time.