If you suffer from long-term acid reflux, regurgitation, heartburn, epigastric discomfort take medication is not effective or once you stop taking medication symptoms relapse, the course of medication is also relatively long, also did a gastroscopy and other tests, what should be the next step? First: first of all, to determine whether the diagnosis is right or not? Our population is large and hospitals of all sizes abound, but there are gaps in diagnostic techniques and levels, and even the same hospital sometimes has a different understanding, so the first step must be to confirm the diagnosis. If the diagnosis is right, there is a way to treat; Second: whether the patient takes the medication according to the doctor’s orders, take the medication to adhere to the course of treatment; Third: if the first and second do, the effect is not good, it is recommended that the patient see the doctor again, the doctor needs further examination; Fourth: according to the different conditions of each person choose different methods of examination, generally if the general patient has the typical symptoms of regurgitation, acid reflux, heartburn, gastroscopy examination has gastroesophageal reflux disease (reflux esophagitis, Barrett’s esophagus, etc.) and the medication does not work well or relapses when the medication is stopped, it is necessary to do esophageal manometry to find out if there are other diseases of the esophagus, especially if there is a hiatal hernia, and also to find out the pressure in the lower esophagus. We found that many patients have poor results because they also have esophageal hiatal hernia. If esophageal hiatal hernia is not treated, acid reflux and heartburn symptoms are difficult to be relieved. Fifth: Other diseases can also cause acid reflux and heartburn, such as gastric insufficiency, gastric sinus lesions, duodenal lesions, diabetes, dermatomyositis, scleroderma, etc. Other factors such as mental factors, uncontrolled diet, stimulating food, lack of sleep, etc. can affect the effect of treatment.