Biological agents are a class of widely used immunobiological agents that can have preventive and therapeutic effects. Biological preparation is a kind of pharmaceutical agent covering a wide range of contents, generally refers to the use of microorganisms and other metabolites in the effective antigenic components, refining and processing, used for the prevention and treatment of the corresponding infectious diseases or other diseases of a kind of biological products. For example, in the field of rheumatology and immunity, biological agents generally refer to monoclonal antibody therapeutic drugs, such as tumor necrosis factor antagonists commonly used in the clinic, such as infliximab, adalimumab, enalaplizumab, golimumab and so on. Clinically for the treatment of systemic lupus erythematosus, ankylosing spondylitis, rheumatoid arthritis, usually have better efficacy.